XenoSTART, the preclinical division of START is a translational research organization focused on creating relevant preclinical cancer models.  Our xenograft models represent each cancer type and disease stage and are established from patients at our domestic and international cancer centers. The XenoSTART Patient-Derived Xenograft (XPDX) platform includes over 2,500 models annotated with each donor patient’s cancer treatment and outcome data and characterized using IHC, DNA/RNA sequencing, and relevant in vivo drug efficacy.

Our XPDX models are clinically annotated and include patient treatment history and outcome and are characterized through genomic profiling, histologic analysis, and in vivo drug sensitivity to relevant standards of care. These models may be utilized in the following manner:

• In vivo PK/PD and efficacy studies
• In vivo efficacy panel screens (indication or target focused)
• In licensing of models for internal studies
• Custom model development
• Orthotopic and radiotherapy studies
• Ex vivo and organoid studies

The Supervisor, Vivarium Operations, will play a crucial role in providing an efficient and compliant vivarium. The role includes overseeing daily vivarium processes and team performance, including scheduling, training, and staff evaluation. This role involves performing PDX studies from industry-sponsored and investigator-initiated studies, ensuring adherence to protocols and compliance with all regulatory and safety guidelines, training and scheduling all procedures related to small animal handling, husbandry, surgery, sterile environments, and dosing. This position will also support the optimization of standard operating procedures and working instructions to ensure quality and effectiveness.

Essential Responsibilities

• Support the Manager, Vivarium in overseeing daily vivarium operations, including supervision of research associates: hiring, onboarding, training, work assignments, time off approval, payroll, performance evaluations, employee development plans, and performance improvement.
• Provide training and hands-on study support on technical procedures, including animal handling, dosing, surgery, tumor implantation, euthanasia, sample collection/processing and data entry.
• Schedule daily tasks, including resolving conflicts and coordinating efforts across multiple teams.
• Create and revise SOPs, working instructions, and other laboratory documentation.
• Monitor animal health and maintain accurate records of experiments and results in compliance with institutional and regulatory guidelines.
• Ensure the health and welfare of animals to maintain compliance with Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) and Institutional Animal Care and Use Committee (IACUC) standards.
• Confirm all study-related documentation is current, accurate, and audit-ready.
• Identify and escalate quality or compliance concerns to the appropriate supervisor or project manager.

Education & Experience

• Bachelor’s degree in animal care or science field.
• 2-4 years of supervisory experience in an animal facility.
• Formal training in animal handling and in vivo research procedures.
• Experience with animal handling, dosing, and necropsy procedures.
• Familiarity with regulatory requirements and ethical standards for animal research.
• Strong communication skills and ability to effectively communicate and present summaries of research results to team members.
• Strong organizational skills with great attention to details and ability to troubleshoot problems.

Preferred Education and Experience:

• Supervisory experience in a preclinical research setting.
• Familiarity with Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC), Institutional Animal Care and Use Committee (IACUC), and OSHA compliance.

Physical and Travel Requirements:

• Ability to stand for extended periods of time.
• Ability to perform daily tasks requires fine motor skills.
• Ability to utilize full range of motion (reaching, bending, etc.).
• Ability to lift 40 pounds.
• Ability to handle and understand safety procedures associated with biological, investigational, or hazardous materials, not to exceed Biosafety Level 2 (BSL2).
• Ability to work with and understand safety procedures associated with Sharps Disposal Containers, including but not limited to needles, scalpel blades, lancets, etc.
• Ability to don full Personal Protective Equipment (PPE) on shift, including but not limited to lab coat, gloves, mask, and bouffant.

Best-in-Class Benefits and Perks

• We value our employees’ time and efforts. Our commitment to your success is enhanced by a competitive compensation, depending on experience, and an extensive benefits package including:
• Comprehensive health coverage: Medical, dental, and vision insurance provided
• Robust retirement planning: 401(k) plan available with employer matching
• Financial security: Life and disability insurance for added protection
• Flexible financial options: Health savings and flexible spending accounts offered
• Well-being and work-life balance: Paid time off, flexible schedule, and remote work choices provided
• Plus, we work to maintain the best environment for our employees, where people can learn and grow with the company. We strive to provide a collaborative, creative environment where everyone feels encouraged to contribute to our processes, decisions, planning, and culture.

More about The START Center for Cancer Research

Deeply rooted in community oncology centers globally, The START Center for Cancer Research provides access to specialized preclinical and early-phase clinical trials of novel anti-cancer agents. START clinical trial sites have conducted more than a thousand early-phase clinical trials, including for 43 therapies that were approved by the FDA. START represents the world’s largest roster of Principal Investigators (PIs) across its eight clinical trial sites. Committed to accelerating passage from trials to treatments, START delivers hope to patients, families, and physicians around the world. Learn more at STARTresearch.com.

Ready to be part of a team changing the future of cancer treatment?

Join us in our mission to conquer cancer, one clinical trial at a time. Your expertise and dedication can help us bring hope and healing to patients worldwide. Please submit your application online.

We are an equal opportunity employer that welcomes and encourages diversity in the workplace. We do not discriminate on the basis of race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical condition, pregnancy, genetic information, gender, sexual orientation, gender identity or expression, veteran status, or any other status protected under federal, state, or local law.